Wendi McLendon-Covey, Allison Tolman, Josh Lawson, Mekki Leeper, Kahyun Kim, Kaliko Kauahi, and David Alan Grier star. The series follows the overworked doctors and nurses working at an underfunded Oregon hospital. St. Denis Medical premiered on November 12, 2024, on NBC. In January 2025, the series was renewed for a second season, which premiered November 3, 2025.