The series follows the overworked doctors and nurses working at an underfunded Oregon hospital. Wendi McLendon-Covey, Allison Tolman, Josh Lawson, Mekki Leeper, Kahyun Kim, Kaliko Kauahi, and David Alan Grier star. St. Denis Medical premiered on November 12, 2024, on NBC. The series was renewed for a second season which is set to premiere on November 3, 2025.