Is The Vaccine coming back?

The Vaccine's return is unconfirmed. The show last aired on December 17, 2021, and its current status is listed as 'Running.' As of May 11, 2026, there has been no official announcement regarding its next season or new episodes.

The Vaccine was a documentary series that aired on ABC News, starting in February 2021. It focused on providing information about the COVID-19 vaccine rollout, featuring expert insights and answering viewer questions. The series aimed to keep the public informed during the pandemic by covering scientific developments and vaccination efforts.

The episodes had a runtime of approximately 15 minutes each, and the series consisted of one completed season with 43 episodes.