Is One Day In My Body coming back?

One Day In My Body is currently airing on TLC; the next episode airs on May 13, 2026.

This series is a documentary-style show that premiered in April 2026. It focuses on individuals living with some of the world's rarest and most complex medical conditions. The program provides an intimate look at their daily lives and the medical challenges they face, highlighting the experiences of those with disorders such as extreme water allergies, rapid aging, and chronic bladder issues.

Each episode has a runtime of 60 minutes.