Is Black Death Patient Zero coming back?

Black Death Patient Zero's return is unconfirmed. The show last aired its second episode on November 17, 2025, and has not announced a new season or episode schedule.

Black Death Patient Zero was a documentary series that aired in 2025 on Sky History. It examined the origins of the 14th-century Black Death pandemic, utilizing new DNA analysis to investigate the earliest victims. The series explored how the plague spread from Central Asia, with filming locations in the UK, Italy, and Germany, and focused on scientific efforts to trace its roots, including studies of plague victims found in Kyrgyzstan in 1338 or 1339.

Each episode had a runtime of 60 minutes.