The first season of Why Women Kill follows three women, each from a different recent era, who reside in the same mansion in Pasadena, California. All three learn of their respective husbands' infidelity during their time in the house. The second season focuses on one storyline set in 1949, with Alma Fillcot, a plain Jane middle-aged housewife who decides to join a Garden Club and Rita Castillo, the same woman inside who despises Alma and the series of murders that follow.