The series premiered on January 26, 2025. It is the second CBS series to adapt the Holmes stories, after Elementary. Morris Chestnut plays Dr. John Watson, a former London-based consulting detective and the head of the Holmes Clinic of Diagnostic Medicine.
One year after Holmes's death, Watson sets up shop at a clinic for the treatment of rare and unusual diseases. Watson must face his past when Moriarty emerges to do battle once more.