U.S. Secret Service agents Myka Bering (Joanne Kelly) and Pete Lattimer (Eddie McClintock) are assigned to the secretive Warehouse 13 for supernatural artifacts. The program follows a team of field agents who retrieve artifacts that have become charged with energy that can give them dangerous powers if misused. Warehouse 13 is the latest in a line of storehouses with infinite capacity that have served this purpose for millennia. The series posits that there have been a dozen incarnations of the warehouse before the present-day 13th in South Dakota.