The series follows U.S. Secret Service agents Myka Bering (Joanne Kelly) and Pete Lattimer (Eddie McClintock) when they are assigned to the secretive Warehouse 13 for supernatural artifacts. The program follows a team of field agents who retrieve artifacts that have become charged with energy that can give them dangerous powers if misused. Once retrieved and neutralized, the objects are stored in Warehouse 13, the latest in a line of storehouses with infinite capacity.