Tyler Hoechlin and Elizabeth Tulloch star as the title characters Clark Kent / Superman and Lois Lane. Jordan Elsass and Alex Garfin portray the couple's twin sons Jonathan and Jordan Kent. The series also stars Erik Valdez, Inde Navarrette, Wolé Parks, Adam Rayner, Dylan Walsh, Emmanuelle Chriqui, Tayler Buck, Sofia Hasmik, Chad L. Coleman, and Michael Cudlitz.
In the first season, Clark Kent / Superman and Lois Lane return to Smallville with their sons Jonathan and Jordan, where they are reacquainted with Lana Lang, her husband Kyle Cushing, and their daughter Sarah. During the second season, Superman's painful visions lead him to an encounter with Bizarro. The third season has Superman contending with the plots of Intergang as Lois Lane suffers from Stage 3 inflammatory breast cancer.