The series premiered on April 16, 2025, on The CW and Discovery+. In 1896, Sherlock Holmes becomes embroiled in a conspiracy involving the Red Thread criminal syndicate. He joins forces with Amelia Rojas, a young Native American woman whose mother was recently murdered. As they work together to crack the case, Amelia also sets out to learn if the great detective is her long-lost father.
Sherlock Holmes is working on a case when an American girl whose mother has been murdered claims to be his daughter.