Samantha Who? is an American television sitcom that originally aired on ABC from October 15, 2007, to July 23, 2009. The show centered on Samantha Newly (Christina Applegate), a vice president of a real estate firm who develops retrograde amnesia after a hit and run accident. Although highly rated during its first season, the sitcom lost momentum and viewers throughout its second season, and ABC canceled the show in May 2009.