Rose Byrne as Sylvia, a stay-at-home mom of 3 and wife who reconnects with her former best friend, Will. Seth Rogen as Will, Sylvia's best friend who's recently divorced. Luke Macfarlane as Charlie, Will's husband who is a lawyer, Luke Hale as Andy (season 1; recurring season 2), Tre Hale as Will's friend and business partner. Sophie Leonard as Frances (season 2; co-starring season 1) as Frances, Sylvia and Charlie's eldest daughter.