The series centers on Osmosis "Ozzy" Jones, a cheeky-chappy white blood cell, and Drix, a level-headed cold pill, who battle germs and viruses inside the body of teenage boy Hector Cruz. The series is set in a stylized version of the human body, which resembles a city where microorganisms and cells are anthropomorphic. It aired on Kids' WB for two seasons and 26 episodes from 2002 to 2004.
Unlike the original film it was spun-off from, Ozzy & Drix was entirely animated and contained no live-action scenes. The voices of Ozzy and Drix were recast with Phil LaMarr replacing Chris Rock as Ozzy, Jeff Bennett replacing David Hyde Pierce as Drix.