The series is produced and animated by TMS Entertainment and its subsidiary 3xCube. The narrative focuses on an underground fighter only known by his ring name Junk Dog, who decides to enter into a boxing competition called Megalonia, in order to defeat the champion, Y?ri. The series was broadcast in Japan from April 6 to June 29, 2018, and was simulcast on Crunchyroll. A second season, titled Megalobox 2: Nomad, aired from April 4 to June 27, 2021.