The hour-long program premiered on November 9, 2009, on cable network TBS. Lopez was the first Mexican-American to host a late-night talk show on an English-language network in the U.S. The show featured audience interaction using a high-energy format. The program aired Monday through Thursday at midnight Eastern and Pacific, immediately following Conan O'Brien. On August 10, 2011, TBS announced that Lopez Tonight would be canceled.