The series features caricatures of members of the George W. Bush administration, and other American and international political figures, most of which are depicted as children. The first season's episodes each consist of two story segments, with each featuring a musical performance by a band composed of main characters. The second season, which premiered on March 13, 2008, consists of ten episodes, and features the full twenty-two-minute storylines including the musical number.
Lil' Bush takes place in an alternate reality version of the present day. George H. W. Bush is president and George W. George Bush (referred to as "Lil' George"), along with his associates, are children attending Beltway Elementary School. Issues in which the latter Bush administration is involved (for example, the Iraq War) are transferred to the elder Bush administration.