The series is based on the DC Comics character of the same name. It follows the adventures of Harley Quinn and her partner Poison Ivy after leaving her boyfriend, the Joker. The show premiered on November 29, 2019. The first and second seasons premiered on DC Universe, before moving to HBO Max for its third season. A standalone holiday-themed special episode premiered on February 9, 2023. The series was renewed for a fifth season, which premiered on January 16, 2025.
The series follows the adventures of Harley Quinn and her journey of self-discovery after breaking up with the Joker. Harley intends to make a name for herself in Gotham City's criminal underworld. The main storyline revolves around the relationship between Harley and Ivy. They form a new crime-fighting team called the Gotham City Sirens.