The series premiered in the United States on April 23, 2010, on Cartoon Network, and concluded on January 3, 2013. It was inspired by the comic M. Rex, created by Aaron Sowd, Joe Kelly and Duncan Rouleau, and published by Image Comics in 1999. A two-part crossover special with Ben 10: Ultimate Alien titled Ben 10/Generator Rex: Heroes United aired on November 25, 2011, while a second 44-minute four-part special, Ben Gen 10, aired on April 11, 2021, featuring new younger versions of the Generator Rex characters.