Evil Con Carne began as a segment on Grim & Evil, in which it and The Grim Adventures of Billy & Mandy aired together. The series aired separately beginning July 11, 2003 and ended its run on October 22, 2004. Following the series' end, its characters would frequently make cameo appearances in Billy and Mandy, with General Skarr becoming a recurring character.
Hector Con Carne (Phil LaMarr) is a wealthy crime lord and evil genius bent on taking over the world and the League of Nations. He was rescued by the scientist Major Dr. Ghastly (Grey DeLisle), who placed his living remains into two containment units: one for his brain, and the other for his stomach. These two units were later installed into Boskov (Frank Welker), a purple Russian circus bear, giving Hector's brain control over (almost) all the bear's movements.