Set in Frank Herbert's Dune universe, the series focuses on the origins of the Bene Gesserit, a powerful social, religious, and political force. Set 10,000 years before the events of Dune, Dune: Prophecy commences 80 years after an alliance of humans defeated the thinking machine armies that had nearly exterminated them.
The series is set 10,000 years before the events of Dune. It follows sisters Valya and Tula Harkonnen as they combat forces that threaten the future of humanity.