The series follows the Systems Commonwealth, an intergalactic government that presided over an extended period of peace and prosperity until its destruction from a rebellion led by the Nietzcheans and parasitic Magog. The series premiered on October 2, 2000, and ended on May 13, 2005. Roddenberry died in 1991, nine years prior to the series premiere.
Thousands of years in the future, the Systems Commonwealth is a constitutional monarchy spanning the Milky Way, Triangulum, and Andromeda galaxies. The Commonwealth is at war with the Magog, a parasitic humanoid species spreading across the galaxies. In response, the Nietzscheans secretly attempted to usurp control of the Commonwealth. Dylan Hunt is the captain of the Andromeda Ascendant, nicknamed "Andromeda"