A.P. Bio premiered on February 1, 2018, on NBC as a mid-season replacement. It aired on NBC for two seasons until June 13, 2019, and moved to Peacock for subsequent seasons. The series is centered around Jack Griffin, played by Glenn Howerton, a disgraced Harvard philosophy professor who returns to his hometown of Toledo, Ohio, to teach advanced placement biology at Whitlock High School. In December 2021, the series was canceled after four seasons.