Hugh Laurie

as Richard Roper

as Dr. Gregory House

as Eric Peterson

as Ryan Clark

as Felix Carmichael

as Major de Coverley

as Dr James Nicholson

as Etienne LeBlanc

as Neville

as The Prince Regent

as Lieutenant The Honourable George Colthurst St. Bartleigh

as Bertram Wilberforce "Bertie" Wooster

as Peter Laurence

as Dr. Eldon Chance

as Leo Hopkins

as Director

as Various Characters

as Paul Slippery

as Various

as Narrator